邢唷> ^a]欹 餜,NbjbjL`趠趠jpvv8 DO4h ::/H      #%T !+/ 4" ///j////;巘CF/8 0h /&.'//& '$C/  h .'v : D桍N ^桼懢|'`仾'`潃巔籰梪o僫r4N奮諎寶 b/gc黐烻R諎L N0(u凈V ,gc黐烻R1uo兞T裿cwt钀钑N4N奮xvzqQ T▼簨6R歔 :N^桼懢|'`仾'`潃巔Nonalcoholic Steatohepatitis NASH 籰梪o僫r剉x裇衏汷b/g鷁畫0,gc黐烻R闟垟鵞NASH4O g>fW劃魚SF2~F4 S靊鉔Pg潃lxS 剉b篘 N塵蔛1Y鉔Pg潃lxSb?Q鍅0 ,gc黐烻R(u嶯Sf[o兞T孴籰梪(uuir6R罷剉o僫rx裇 臢\O:N╟P'`鷁畫0(W擽(u,gc黐烻R鰁 貜擽 T鰁耂齎E柡N(uo兞T鑜孮b/gOSOThe International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use ICH 孴vQ諲齎匭Y騗裇^剉鴙sQb/gc黐烻R0 ,gc黐烻R\鶺嶯褃f[xvz蹚U\蹚Nek鬴癳0t拵NNASH籰梪o僫r4N奮x裇-NsQ.晛 }剉蹚U\孴鬴癳艔 ,gc黐烻R臢鉔h圫_MR鷁畫0 孨0俰饛 ,gc黐烻R;N亯▼簨NASH籰梪o僫rx裇-N4N奮諎寶緥剉蛻筽sQ鑜匭筟0sQ嶯4N奮諎寶緥b邁f[R恎剉N,'`顣槝颯耂vQ諲鴙sQc黐烻R0 N 歔IN ^桼懢|'`仾'`潃舥Nonalcoholic Fatty Liver Disease NAFLD /fN蛓N饊沑 }礲梑孴W Ofa芠R鴙sQ剉鉔"寯^纎'`潃乢c$O 緐舥1S靊^桼懢|'`潃仾豐Nonalcoholic Hepatic Steatosis I{ T^桼懢|'`仾潃NAFL0Nonalcoholic fatty liver0 0^桼懢|'`仾'`潃巔Nonalcoholic Steatohepatitis NASH 蔛NASH鴙sQ潃lxS孴潃苸迉Lv0NASHh埌s:N5%錘 N剉潃苸迉仾豐Tv^\鯯匭巔莡孴潃苸迉lt7h豐'`0 孨 AmL埮uf[ NAFLD/fhQtAmL垊v;N亯潃伨u舥KNN g噀.sS hQt舥噑:N25.24%95% CI 22.10-28.65 N舥噑恡^瀀燫0eg陙 Nwm0S琋I{0W:S剉AmL埮uf[屽g觺済>f:y nfb篘B媁厤餢蕥璭剉NAFLD舥噑10t^g魰蜰15瀀燫0R31錘 N0NASH(WTv^鉔"岦~T乢02媁謡?\舥剉NAFLD-N纇鶴噑貧0NASH/f黐魜潃lxS剉;N亯烻郪KNN NASH10~15t^匭潃lxS裇u噑貧緩15%~25%0胈@垺{緐舥0v`'`縺$v孴潃lxS1Y鉔P/f_w峃ASH{k剉8^翂烻郪0  N 籰梪o僫r 籰梪顅hg葉顅剉/f鯺0;朾k0恖廚ASH剉蹚U\ 9e刄4N奮觺@\ S靊M朜O潃lxS蔛vQv^裇莡剉裇u M朜O潃鹹 i剉桞l 衏貧X[;m噑 9e刄u;m(嵪慖{0 籰梪o僫r顅MR\鄀惽弿:g鵞gq4N奮諎寶nx翄 gHe'`孴塠hQ'`剉籰梪o僫r N^0 N04N奮諎寶緥 N ;`SOQ o僫rx裇4N奮諎寶剉緥鶺嶯4N奮諎寶顅剉 歔09hnc籰梪NASHo僫rv椆p N T 6R歔4N奮諎寶筫Hh0 1.譙諎 NASH蕥璭=\潃膥莮f[纇錱X[(W gR'`0諷7h孴膵鱊飲頬I{@\P'` FO蚇6q/f顅MRNASH蕥璭剉 褢h芉 0(WNASH o僫rx裇-N 潃膥莮舥tf[/fnx翄'`4N奮諎寶-N譙諎蕥璭蔛;N亯葉筽剉膵鱊ch0NAFLD/NASH剉膥莮f[膵鱊鹼邁;N亯S靊 Brunt鹼邁0齎NASH4N奮xvzQ軂膵R鹼邁NASH-CRN 0'k2m仾潃蹚U\;柇e膥莮f[膵R鹼邁Fatty Liver Inhibition of Progression FLIP-SAF I{0 煴R"}鄀Rh譥ir\O:N閑gRek[{ 怤ASH譙諎剉筫誰 vQ-NS靊ALTI{@nuSch孴y佽悈嶐X08h義qQ/cb螾I{q_螾f[ch0 2.葉筽ch膵鱊 gHe'`膵鱊葉筽S靊4N奮觺@\葉筽孴潃膥莮f[f鉔葉筽 錘蔛@nuS纇錱0q_螾f[纇錱I{vQ諲"}'`葉筽0 1 4N奮觺@\膵鱊 鵞嶯NASH鄀潃lxS剉 4N奮葉筽S靊蹚U\髞潃lxS0鶴皊1Y鉔P婲鯪y4l0邩脌昢Y 侐f _鶴@b潃'`伵uI{ 0潃鹹 i0潃苸迉Lvb潃舥鴙sQ{k/hQ郪{kI{婲鯪0 鵞嶯NASH潃lxS鉔Pg剉 4N奮葉筽S靊鶴皊1Y鉔P婲鯪0潃鹹 i0潃苸迉Lvb潃舥鴙sQ{k/hQ郪{kI{婲鯪0 2 潃膥莮舥tf[膵鱊 潃膥莮舥tf[膵鱊chS靊仾'`潃巔0魚S剉9e刄0 膥莮舥tf[膵鱊(嵪懽SY蛓郪 }q_蚑 S靊;m纇筫_0;m纇{|媁梶垟z:R/Tib_;m纇 0z:R钀MO0z:R垟膲 T V n  疳涯殉肠檶reX檶KKrhN-hCJ PJaJ hh鉉CJ PJaJ hph鉉CJ PJaJ hN-h鉉CJ PJaJ hN-h鉉CJ PJaJ h&/h鉉CJ PJaJ hh鉉CJ PJaJ hph鉉CJ PJaJ hN-h鉉CJ PJaJ sHtHhCCJ,OJPJaJ,o(h,h鉉CJ,OJPJaJ,o(hCCJ OJPJQJaJ o(h@CJ OJPJQJaJ o(,BDRv t ~   *剙d@&WD`剙gdN-剙d @&WD`剙gdN- 剙d WD`剙gdN- 剙dWD`剙gdN- $da$gdN- $d潺a$gdN-gd@ (*jPZJ PxzDXp箧偬刻刻搀尜虦姴箧偬蘲蘲eXKh&/h,|CJ PJaJ hh鉉CJ PJaJ hph鉉CJ PJaJ hN-h衊CJ PJaJ hN-h鉉CJaJ#hN-h鉉5丆J OJPJQJaJ +hN-h鉉5丆J OJPJQJaJ nHtHhN-h鉉CJ PJaJ hN-h,|CJ PJaJ hN-h鉉CJ PJaJ h&/h鉉CJ PJaJ hh鉉CJ PJaJ hph鉉CJ PJaJ  z>.BRj8Jx:L&2<L 剙dWD`剙gdN- 剙dWD`剙gdN-剙d@&WD`剙gdN-剙d@&WD`剙gdN-p4@BNXhj>HJ@JLpz,0b0 6 J L P ` ###$$x$%22222N5箧筚筇坎筇坎筇坎筇坎箧筇坎螗構~搀袤炭搀|筇坎Uhh}CJ PJaJ hh鉉CJ PJaJ hph鉉CJ PJaJ hN-h鉉CJ PJaJ h&/h鉉CJ PJaJ hh鉉CJ PJaJ hph鉉CJ PJaJ hN-h}CJ PJaJ hN-h,|CJ PJaJ hN-h鉉CJ PJaJ -L~"t0 L ` *!!x"##$$$%2225*5 剙dWD`剙gdN-剙d@&WD`剙gdN- 剙dWD`剙gdN-賬o傿R蠎孴籰梪c韣鰁魰亯9hnc\O(u:g6R蔛鵞嶯@b 悧uHech剉剺g\O(ueg緥 擽 g硩Y晞v葉筽聣遊鰁魰0鷁畫鍕6柕k"}Y*NBR蠎\O:NT韣緥剉 愰b0 2 Tg"} 緥塠paBR鵞gq0彇:g0蘏騰緥0 譙諎eQ Q唗^劅0'`+R0蕥璭h芉0緐舥%N蛻 z0Tv^緐舥I{0鷁畫硚eQ蟸潃膥莮舥tf[nx蕥剉NASH 潃膥莮;m纇髞eQ膥剉鰁魰梲N, N厤菑6*Ng (W鍕鰁魰梲匭楄la/f&T譙颯齹q_蚑潃膥莮f[豐S剉r^剺0鵞嶯NASH鄀潃lxS剉 顅MR鷁畫剉;N亯eQ膥h芉NAS膵Re"4R vQ-N巔莡孴lt7h豐T髞\1R T鰁 F2d"CRN魚SF40鵞嶯NASH潃lxS鉔Pg剉 (W潃膥莮舥tf[nx蕥NASH剉鶺@x N 貜擽 g潃lxS剉膥莮舥tf[翄nc0;N亯抍dh芉ALT孴ASTGS貧厤菑ck8^ NPULN 剉5 P 苺 }GS貧厤菑1.5 PULN MELD膵R12R CTP膵R6R Tv^vQ諲潃伨u舥剉NASH0 ;N亯梪Hech 錘膥莮f[9e刄:N;N亯梪Hech鰁 ╟P = 1 \* GB3 `$NASH9e刄 T鰁魚S鄀v`Sb  = 2 \* GB3 a$潃膥莮魚S9e刄1R蔛錘 N T鰁NASH鄀v`Sb  = 3 \* GB3 b$NASH9e刄 T鰁潃膥莮魚S9e刄1R蔛錘 N0NASH9e刄歔IN:NNAS膵R髞\M朜O2R vQ-Nlt7h豐髞\M朜O1R 仾豐膵R N瀀燫0NASH鄀v`S歔IN:N(WNAS膵R-N剉巔莡0lt7h豐孴仾豐膵RGW N瀀燫0 鵞嶯NASH潃lxS鉔Pg剉 _N颯錘 愰b4N奮觺@\葉筽\O:N;N亯梪Hech0 賬o傿R蠎孴籰梪c韣鰁魰颯緥nY*NBR蠎膥 膵鱊o僫r剉蠎HesQ鹼0擽軴翄硩Y晞vxvz鰁魰錘聣遊膥莮f[9e刄 髞\亯緩0R12^18g0 3.nx翄'`4N奮諎寶 緥塠paBR鵞gq0彇:g0蘏騰緥0 譙諎0賬o傿R蠎孴籰梪c韣鰁魰 TTg"}'`4N奮諎寶0 ;N亯梪Hech 鵞嶯NASH鄀潃lxS剉 顅MR颯譙剉潃膥莮舥tf[f鉔葉筽S靊仾'`潃巔孴/b魚S剉9e刄0 鵞嶯NASH潃lxS鉔Pg剉 俌済 愰b潃膥莮舥tf[\O:Nf鉔葉筽 擽 gEQR剉褃f[漁nc v^婲HQNo兞T裿cwt钀钑蹚L垷l0 錘膥莮f[9e刄:N;N亯梪Hech鰁 ╟P`$NASH銐 T鰁 魚S鄀v`Sb a$潃膥莮魚S9e刄1R蔛錘 N T鰁NASH鄀v`Sb b$NASH銐 T鰁潃膥莮魚S9e刄1R蔛錘 N0NASH銐歔IN:NNAS膵R-N巔莡膵R:N0-1R lt7h豐膵R:N0R 仾豐膵R N瀀燫0NASH鄀v`S歔IN:N(WNAS膵R-N剉巔莡0lt7h豐孴仾豐膵RGW N瀀燫0 1u嶯NASH剉籰梪颯齹梺g go 擽Q哱PoT彇繈0 (Wnx翄'`4N奮諎寶 T鰁颯蹚L垽SOo冦N≧汻f[xvz0o僫r鶺郪膥f[xvzI{0 4.nx翄4N奮穬蕍剉諎寶 t拵N膥莮f[9e刄剉f鉔葉筽N4N奮觺@\剉鴙sQ'`\*gnx藌 擽蹚L4N奮諎寶nx翄4N奮觺@\剉穬蕍0 ╟P冨N N YT葉筽鶴皊1Y鉔P婲鯪y4l0邩脌昢Y 侐f _鶴@b潃'`伵u 0潃鹹 i0MELD膵Re"150潃苸迉Lv0hQ郪{k0鵞嶯NASH鄀潃lxS剉 貜S靊蹚U\髞潃lxS0  N 塠hQ'`膵鱊 1u嶯NASH梺曵e魰剉迯韣 go 郪dk梺 g硩Y剉磃2椣憣T磃2楒e魰蹚L垑[hQ'`聣遊0鷁畫(Wg諎寶-N緥藌靣藌剉褃f[訷XTO0 NASH4N奮諎寶-N擽yr+RsQ鑜錘 N颯齹剉 No倠N鯪 1.潃 No倠N鯪1u嶯NASH鵞o僫r@b魜剉潃_c$OOea'`瀀燫 g鰁o僫r颯齹駤裇潃_c$O燫蛻 緥4N奮諎寶鰁擽\購N颯齹'`Q(W匭0擽=\蠎nx歔潃_c$O燫蛻剉烻郪 貜擽yr+RsQ鑜\PoT蚐髰'`潃烺齹_8^0鵞嶯 g\o(W潃佉k'`剉o僫r 擽(W4N奮諎寶-N緥藌裿KmR0 2.線 No倠N鯪1u嶯NASH,g珟O瀀燫ba'`線伨u舥剉螛i (W諎寶MR孴諎寶菑 z-N亯hQb椖0O孴裿Km譙諎剉線仧R齹0 3.胈@垺{ No倠N鯪胈@垺{婲鯪/fNASH剉;N亯{k郪 擽9hnco僫r剉yr筽 裿Kmo僫r鵞胈@垺{鹼邁剉q_蚑0 4.鉔"寣T匭R蘬 No倠N鯪NASH8^Tv^鉔"岦~T乢 擽9hnco僫r剉yr筽 裿Km鵞SO蛻0@堉|I{鉔"ch剉q_蚑0 踁0耂噀.s 1.^桼懢|'`仾'`潃舥蕥梪2柣lcWS2018鬴癳Hr .-NNS潃伵uBg譥 2018 263 195-203. 2.潃魚S蕥璭蔛籰梪qQ茓2019t^ .4N奮潃苺舥Bg譥 2019 3510 2163-2172. 3.NMPA.o僫r4N奮諎寶剉N,Qc黐烻R.2017t^1g 4.Sanyal AJ, Friedman SL, McCullough AJ, et al. Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: findings and recommendations from an American Association for the Study of Liver Diseases U.S. Food and Drug Administration Joint Workshop [J]. Hepatology, 2015 614 :1392-1405. 5.Angulo P, Kleiner DE, Dam-Larsen S et al. Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease [J]. Gastroenterology, 2015,149:389 397. 6.Younossi ZM Koenig AB Abdelatif D et al. Global epidemiology of nonalcoholic fatty liver disease meta-analytic assessment of prevalence incidence and outcome [J].Hepatology 2016 641 73-84. 7.Sanyal AJ Miller V. Regulatory science and drug approval for alcoholic and nonalcoholic steatohepatitis [J]. Gastroenterology, 2016,1508 :1723 1727. 8.Hannah WN, Torres DM, Harrison SA. Nonalcoholic steatohepatitis and endpoints in clinical trials [J]. Gastroenterology & Hepatology 2016,1212 :756-763. 9.Patel YA, Imperial JC, Muir AJ et al. Baseline parameters in clinical trials for nonalcoholic steatohepatitis : Recommendations from the Liver Forum [J]. Gastroenterology, 2017,153:621 625. 10.Siddiqui M S, Harrison S A, Abdelmalek MF, et al. Case definitions for inclusion and analysis of endpoints in clinical trials for nonalcoholic steatohepatitis through the lens of regulatory science [J]. Hepatology, 2018,675 :2001-2012. 11.Cheung A, Neuschwander Tetri BA, Kleiner DE, et al. Defining improvement in nonalcoholic steatohepatitis for treatment trial endpoints: Recommendations from the Liver Forum [J]. Hepatology, 2019,705 :1841-1855.       PAGE \* MERGEFORMAT2   PAGE \* MERGEFORMAT3    PAGE \* MERGEFORMAT1   N5P5h5j5l5n5v55555555555666 66,6>67799&9D9F9V9f9|9~9999;;钺芯瓲擃嵝经爴嗩嵝经爴嗎y峋爴緺搯緺搯醠hN-h鉉CJ PJaJ hN-h}CJ PJaJ h&/h鉉CJ PJaJ hh鉉CJ PJaJ hph鉉CJ PJaJ !jhh鉉CJ PJUaJ #hN-h鉉CJ OJQJ^JaJ o(!jhN-h鉉CJ PJUaJ hN-h鉉CJ PJaJ !jhph鉉CJ PJUaJ '*56 777788~88L::::8;;;p<<=>x>>剙d@&WD`剙gdN- 剙d WD`剙gdN- 剙dWD`剙gdN-;;;<<<<<====>>>>0>v>x>z>|>>>>>>?$?&?^?b????????@@谹箧偬坎ベ炭播偬坎ベ炭播購播賯蘵蘦蘵h蘦蘵hN-h,|CJ PJaJ hN-h}CJ PJaJ h&/h,|CJ PJaJ +hN-h鉉5丆J OJPJQJaJ nHtHhh鉉CJ PJaJ hph鉉CJ PJaJ hN-hCJ PJaJ hN-h鉉CJ PJaJ h&/h鉉CJ PJaJ hh鉉CJ PJaJ hph鉉CJ PJaJ (>>^??@夿HD蔈鶩0H癐怟>M@MBMDMFMHMJMNMPMTMVMZM凾鸙DWDp凾`鹓d@gd@剙dG$H$WD`剙gdN-剙d@&WD`剙gdN-谹贏夿嶣DHDLD蔈蜤霧頕鶩﨔0H4H癐禝怟朘翶腒>M@MBMHMJMLMPMRMVMXM\M^MbMdMhM蹊坭蹊坭坭蹊坭坭蹊坭坭设酣檴倊倊倊倊mahN-h&UCJaJo( hN-h&UB*CJaJo(phh jh Uh&UCJOJPJQJaJo(h@CJ OJPJQJaJ o(#h鉉h@CJ OJPJQJaJ o(h鉉CJ OJPJQJaJ o(#hN-h鉉CJ OJQJ^JaJ o(hN-h}CJ PJaJ hN-h鉉CJ PJaJ hN-h鉉CJ aJ &ZM\M`MbM燤釳銶鍹$N&N(N*N,Ngd@ $4$a$gdN- $4$a$gd淣hMjM擬朚楳歁濵燤∕狹訫諱豈贛轒郙釳鍹闙霱NNNN N"N$N&N(N*N疱鹩鹎迕韩牜荧簭垊丘屦羽莝d`\Xh h!h&UhN-h&UB*CJaJph hN-h&UB*CJaJo(phhv h淣h淣 h淣h淣B*CJaJo(phh淣h淣CJaJjh淣h淣CJUaJh淣CJaJo(h zhN-h&UCJaJo(#h xh xCJaJmHnHsHuhN-h&UCJaJjhN-h&UCJUaJ*N,Nh&UCJOJPJQJaJo(J 00P&P 182P:pN-皞. 捌A!胞"胞#悎$%癝斑 惄Dp砷詠;糀瀕K@縴鉤砷詠;糀瀕K@縴鉤砷詠;糀瀕K@縴鉤砷詠;糀瀕K@縴鉤砷詠;糀瀕K@縴鉤砷詠;糀瀕K@縴鉤砷詠;糀瀕K@縴鉤砷詠;糀瀕K@縴鉤砷詠;糀瀕K@縴鉤砷詠;糀瀕K@縴鉤b 002 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~PJ_HmH nHsH tHJ`J ck噀 $1$a$ CJKH_HaJmH nHsH tH$A $ 貫祂=刉[SOBiB nf恏赝3縗`?/[G殁\!-跼k.搒曰..椃碼婵?PK!ブх6 _rels/.rels剰蟡0 囷吔冄}Q颐%v/C/(h"脎O 劋秣=畫旂 毆免C?薶醰=偵叅%[xp啠{鄣_糚眩<10堎O糝瓸d焉襃E4b$q_槥6L吁R7`畯ㄉ趁0虨O,錏n7擫i鋌〃/鉙綈╡械根铸PK!kytheme/theme/themeManager.xml 蘉 @醹愘7c(Eb菜CA菭覠圩邈7芜諞K Y, 奺.埛饇,ㄚH,l崆骈x纱逫萻Q}#諓叚递 值+!,較$j=婫W栌)釫+& 8PK!mQtheme/theme/theme1.xml靁MoE#F{oc'vGuh覨盵糟x=逎zvg53Nj廐H垈z饴昛 $石I)*E阓酀欇鮊&IA!裎>秣羌3緓镹男>掤搁U蟇L0斈屵呖z迃rx鳔脅稔h9T8奣/魁煜?鍃Y雒'蟸3S琦棌~蜩鶅O_|w)馉镉圚t=乤+d NG1-Rl苼1諶J鴚T锠疢1Kc柩"o he浪撣幝絇L-憒%绗臙甴Y7'qP.\L姼=岟薲穛炷3I爋fi墸.帽墘BRb-J款P_p蒅 茛▍i㎏鷗郿訉h汧梚櫷o7;7Q嫵2染媱珼>a/銐翾>嶺厌W 藬霱卂膗H剄)薶 胺+:Vi豾4r態裶汐橌"r嫃!帓2l徠a麃C奲此U|嚮!8^顩8>軤仯,A魶壭眲V韙鄨讕厏ls囔14犁_=,涩返o聻TV 跥陲"苎鎎H唼灮'.4熯x薜躻-戏蹺鮸褾;氕衯踯`嘼3"G 'e\昮H柊O 话ㄩ恬愪'$劘i_wp伬 >*靺8魂i&丩Y%\铝,楎謝視=瞩伭壵阱綔 r6f 提3储淭厥厰)橗:陋ZK誏玸ゅ&C 鏜兣軟0 [浪玴@注醏j扣7 媺耏咹唜Hi荤cT5A蕆跑@顢腍驇馴AZC硙i' RQ\m伕,zo,僩Q襲{Y\,Nψ/=溷ら嵿L _.跆嘫7C6韽-fS宄h62密"5咍麥罭H凾[X65太4X%Y龡豚殖2纅鷎h辈绅痠~tCKF#猥b +趙1m鑵4`眹!:U翞!昿5a:倊{4韒笫m蝘o 萎c杽8m泛D矹秔S枪姗豓1铘?#S奿?3E'pS2疳W`る甸q]( ┻08樲w别 n撏A鲺[s枃)k8皓= Aa?R d趻删c楿咏瞬d)#換ueb恾满捷C!ず&i0福>4魫S7鋥z虮 F箎 4sKvUKo瘸椒h垀1砵YU奥V蠬塔5U8錠k;譁潘鮈9堚寂皹D 荀 ?*|FL 迪鳡"A3兇伂>g类dm2iV值殍そ杕謌<殒r8[kv抶熞蠃p鎶sj,潩z伛礭[鑚堨叆Qv11縤u鈨-高0%M2羙J描3u舘%覎PK! 褠煻'theme/theme/_rels/themeManager.xml.rels剰M 0匃倃oo雍&輬协勪5 6?$Q祉 ,.嘺緳i粭澤c21h:闀q毩m胳嶡RN壻;d癭値o7g慘(M&$R(.1榬'J摐袏T鶂8V"&A然蠬鱱}狇|$絙{朠除8塯/]As賲(⑵锑#洩L蔥汉倪PK-!倞[Content_Types].xmlPK-!ブх6 +_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!mQtheme/theme/theme1.xmlPK-! 褠煻' theme/theme/_rels/themeManager.xml.relsPK]  ` -NNor pN5;谹hM*N,N(*,./L*5>ZM,N)+-ly{"晞"晞"晞%'/EGPfhr!晙!晙!晙餈  (@餒 0(  饞'0(  養 S  ? _Toc536430367 _Toc536430368 _Toc536430369 _Toc536430370 _Toc536430371 _Toc536430372 _Toc536430373 _Toc536430374 _Toc536430375 _Toc536430376 _Toc536430377 _Toc536430378 _Toc536430379_GoBack _Toc536430380 _Toc536430381 _Toc536430382$ }  & ) ( % / 4 jlmoprsuvwjlmoprsuv")} & & 0 Bijlmoprsuvyeijjlmmoprsuvy詘=5"'m搉U7!(d)   Bg . p鑅+X}2 `Z頵膠譖躾e}唃,I篳B(膤?夿iK VO!/$$!8'}' Q*S*(++^, -=-L/&/,/\)20355/5k26雙7/E;F;/<6J<=鬬=竱>鋃@B;E2G郳G鬑JvuM'OPT!TM2V%FVfVIg i^=mn肞nJGo梪rFPsov yw x>{欯{,|羠|bl罝Y IV馱5<y_竁 ~猙F蝆膖1m)b0lyF鉉}C衊頸M!)-@e|:C淣塓鉚 2鏠{b#艶黐 (,:講3-趓猺er:8X鳨DqZv鱊_5l# W畁r爔*+5%!+ett z?奲l#j硄d:Tr"籅C\6橺 pv7&U1 N- $P3}vGKb(E[h萡">DMuRdjl@XX2Unknown G*郃x Times New Roman5Symbol3. *郈x Arial;= 鷟8褳SOSimHeiY筫ck\h媅{SOArial Unicode MS]5  N媅_GB2312Arial Unicode MS]5  wiSO_GB2312Arial Unicode MS;(媅SOSimSun1NS噀N媅A$BCambria Math!h專|=- 3=- 3-!),.:;?]}    & 6"0000 0 0 00000 =@\]^([{  0 0 00000;[i個r\\ 3僸HX?萡2! xx@\裇噀_7h Xtzj.Userhaierd  0@P`p 这駃 嶐Z'櫟`激禝嶏Z'櫟鄥燆鵒h珣+'迟0P     $08@H(局发文式样) Xtzj.UserNormalhaier2Microsoft Office Word@F#@,kT@秆c@秆c =-胀諟.摋+,0 X`t|  Xtzj.Com3\   !"#$%&'()*+,-./02345678:;<=>?@ABCDEFGHIJKLNOPQRSTVWXYZ[\_`cRoot Entry F鹛辴bData 11Table9.'WordDocument L`SummaryInformation(MDocumentSummaryInformation8UMsoDataStore衸媡;巘R0Y523W4QPUL==2衸媡;巘Item  PropertiesUCompObj u   F#Microsoft Office Word 97-2003 文档 MSWordDocWord.Document.89瞦